Attenuation of Human Enterovirus 71 High-Replication-Fidelity Variants in AG129 Mice
نویسندگان
چکیده
منابع مشابه
Attenuation of human enterovirus 71 high-replication-fidelity variants in AG129 mice.
UNLABELLED In a screen for ribavirin resistance, a novel high-fidelity variant of human enterovirus 71 (EV71) with the single amino acid change L123F in its RNA-dependent RNA polymerase (RdRp or 3D) was identified. Based on the crystal structure of EV71 RdRp, L123 locates at the entrance of the RNA template binding channel, which might form a fidelity checkpoint. EV71 RdRp-L123F variants genera...
متن کاملBlocking human enterovirus 71 replication by targeting viral 2A protease.
OBJECTIVES Human enterovirus 71 (EV-71), a member of the Enterovirus genus, constitutes a major public health issue in the Asia-Pacific region, where it is associated with several severe neurological complications. There is currently no effective vaccine or antiviral against EV-71. The aim of this study was to determine whether the six amino acid peptide LVLQTM, which was previously shown to in...
متن کاملRecombinant Human Enterovirus 71
Hand, foot and mouth disease (HFMD) is a common illness of infants and young children <10 years of age. It is characterized by fever, ulcers in the oral cavity, and rashes with blisters that appear on the palm and sole. The most common causal agents of HFMD are coxsackievirus A16 (CV-A16) and human enterovirus 71 (HEV71), but other enteroviruses, including CV-A5 and CV-A10, can also cause it. W...
متن کاملCOPI Is Required for Enterovirus 71 Replication
Enterovirus 71 (EV71), a member of the Picornaviridae family, is found in Asian countries where it causes a wide range of human diseases. No effective therapy is available for the treatment of these infections. Picornaviruses undergo RNA replication in association with membranes of infected cells. COPI and COPII have been shown to be involved in the formation of picornavirus-induced vesicles. R...
متن کاملimpact of human enterovirus 71 genotypes in meningoencephalitis in iran
conclusions the c genotype should be considered as the prevalent ev71 circulating genotype in iran, particularly in cases of aseptic meningitis. patients and methods viral rna was extracted from 170 cerebrospinal fluid samples obtained from children aged under 8 years with a primary diagnosis of aseptic meningitis. specific ev71 pcr was conducted to identify the genotype of the detected ev71 vi...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2014
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.00289-14